Colistin resistance plasmids dually enhance bacterial virulence and antibiotic resistance via surface polysaccharide biosynthesis

Abstract Plasmids carrying the mobilized colistin-resistance gene mcr-1 are prevalent among multidrug-resistant Gram-negative pathogens, yet their broad impact on bacterial physiology and virulence remains unclear. Here, we demonstrate that acquisition of an mcr-1 plasmid concurrently increases anti...

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Hauptverfasser:	Eunbyeol Ahn, Jinshil Kim, Junyao Jiang, Joonbeom Kim, Artur Muszyński, Katarzyna Kasperkiewicz, Hojun Shin, Yingqi Cao, Yejin Soh, Youngjae Park, Christian Heiss, Liyanage Devthilini Pasasum Fernando, Parastoo Azadi, Yang Wang, Byeonghwa Jeon, Sangryeol Ryu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-11-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-025-65412-9
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