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Association between Prostinogen (KLK15) genetic variants and prostate cancer risk and aggressiveness in Australia and a meta-analysis of GWAS data.

<h4>Background</h4>Kallikrein 15 (KLK15)/Prostinogen is a plausible candidate for prostate cancer susceptibility. Elevated KLK15 expression has been reported in prostate cancer and it has been described as an unfavorable prognostic marker for the disease.<h4>Objectives</h4>We performed a comprehensi...

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Principais autores: Jyotsna Batra, Felicity Lose, Tracy O'Mara, Louise Marquart, Carson Stephens, Kimberly Alexander, Srilakshmi Srinivasan, Rosalind A Eeles, Douglas F Easton, Ali Amin Al Olama, Zsofia Kote-Jarai, Michelle Guy, Kenneth Muir, Artitaya Lophatananon, Aneela A Rahman, David E Neal, Freddie C Hamdy, Jenny L Donovan, Suzanne Chambers, Robert A Gardiner, Joanne Aitken, John Yaxley, Mary-Anne Kedda, Judith A Clements, Amanda B Spurdle
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2011-01-01
coleção:PLoS ONE
Acesso em linha:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0026527&type=printable
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