Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson’s disease: implication of acrolein and TRPA1

Abstract Background The mechanisms underlying lesions of dopaminergic (DA) neurons, an essential pathology of Parkinson’s disease (PD), are largely unknown, although oxidative stress is recognized as a key factor. We have previously shown that the pro-oxidative aldehyde acrolein is a critical factor...

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Detalhes bibliográficos

Principais autores:	Liangqin Shi, Yazhou Lin, Yucheng Jiao, Seth A. Herr, Jonathan Tang, Edmond Rogers, Zhengli Chen, Riyi Shi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-04-01
coleção:	Translational Neurodegeneration
Assuntos:	Oxidative stress Parkinson’s disease Neuroinflammation Acrolein TRPA1 Dimercaprol
Acesso em linha:	https://doi.org/10.1186/s40035-021-00239-0
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