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Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction

Myelination of axons facilitates rapid impulse propagation in the nervous system. The axon/myelin-unit becomes impaired in myelin-related disorders and upon normal aging. However, the molecular cause of many pathological features, including the frequently observed myelin outfoldings, remained unknow...

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Principais autores: Julia Patzig, Michelle S Erwig, Stefan Tenzer, Kathrin Kusch, Payam Dibaj, Wiebke Möbius, Sandra Goebbels, Nicole Schaeren-Wiemers, Klaus-Armin Nave, Hauke B Werner
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2016-08-01
Serier:eLife
Fag:
glial cells
myelinated axons
neuropathology
myelin structure
label-free proteomics
septin cytoskeleton
Online adgang:https://elifesciences.org/articles/17119
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