Aortic valve-specific genes dysregulated in calcific aortic valve stenosis as potential biomarkers and therapeutic targets

Summary: Calcific aortic valve stenosis (CAVS) is the most frequent heart valve disease. Elucidating specific gene expression patterns in the aortic valve could provide new insights for understanding disease pathophysiology. We used local RNA sequencing data from 500 explanted human aortic valves to...

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Main Authors: Pardis Zamani, Ursula Houessou, Hasanga D. Manikpurage, Zhonglin Li, Manel Dahmene, Nathalie Gaudreault, François Dagenais, Marie-Annick Clavel, Philippe Pibarot, Benoit J. Arsenault, Patrick Mathieu, Yohan Bossé, Sébastien Thériault
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2025-07-01
Series:HGG Advances
Assuntos:
calcific aortic valve stenosis
transcriptomics
biomarkers
gene expression
plasma proteins
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S266624772500051X
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