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Two-Step Size-Exclusion Nanofiltration of Prothrombin Complex Concentrate Using Nanocellulose-Based Filter Paper

<b> </b>Coagulation Factor IX-rich protrhombin complex concentrate (FIX-PCC) is a therapeutic biologic product that consists of a mixture of several human plasma-derived proteins, useful for treating hemophilia B. Due to its complex composition, FIX-PCC is very challenging to bioprocess through viru...

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Principais autores: Levon Manukyan, Athanasios Mantas, Mikhail Razumikhin, Andrey Katalevsky, Eugen Golubev, Albert Mihranyan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-03-01
coleção:Biomedicines
Assuntos:
mille-feuille filter
cladophora cellulose
hemophilia b
protein aggregates
virus removal filtration
Acesso em linha:https://www.mdpi.com/2227-9059/8/4/69
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