Pd(II)–NHC (NHC = N‐Heterocyclic Carbene)‐Catalyzed Alkylation of Primary Amides by Site‐Selective N─C(O) Activation

Abstract Although over the past decade, there have been tremendous advances in amide bond cross‐coupling, one of the major remaining challenges is selective alkylation of ubiquitous primary amides. Herein, a highly efficient method for Pd(II)–NHC (NHC = N‐heterocyclic carbene)‐catalyzed alkylation o...

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Autores principales:	Peng Lei, Yuge Hu, Deshuang Zhang, Jiuhui Ye, Yanqing Gao, Juntao Feng, Zhiqing Ma, Xili Liu, Michal Szostak
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2025-12-01
Colección:	Advanced Science
Materias:	alkylation N–C(O) activation N‐heterocyclic carbenes Pd–catalysis primary amides
Acceso en línea:	https://doi.org/10.1002/advs.202511827
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