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Sialyl-Tn expression correlates with reduced c-Myc and immune modulation in triple negative breast cancer

Abstract Triple negative breast cancer (TNBC) is an aggressive, heterogeneous cancer with lack of targeted therapies. The cancer-associated sialyl-Tn (STn) antigen has a significant role in cancer, yet its involvement in TNBC remains unexplored. This study investigates STn’s role in TNBC, analysing...

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Principais autores: Rita Adubeiro Lourenço, Daniela Ferreira Barreira, Carla Lopes, Pedro Granjo, Ana Sofia Rodrigues, Zélia Silva, Manuela Martins, Ana Rita Grosso, Paula A. Videira
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-10-01
coleção:Scientific Reports
Assuntos:
Triple negative breast cancer
Sialyl-Tn antigen
ST6GalNAcI
ST6GALNAC1 gene
C-Myc
Immune evasion
Acesso em linha:https://doi.org/10.1038/s41598-025-21496-3
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