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RBD-depleted SARS-CoV-2 spike generates protective immunity in cynomolgus macaques

Abstract The SARS-CoV-2 pandemic revealed the rapid evolution of circulating strains. This led to new variants carrying mostly mutations within the receptor binding domain, which is immunodominant upon immunization and infection. In order to steer the immune response away from RBD epitopes to more c...

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Autori principali: Hélène Letscher, Delphine Guilligay, Gregory Effantin, Axelle Amen, Guidenn Sulbaran, Judith A. Burger, Laetitia Bossevot, Laura Junges, Marco Leonec, Julie Morin, Matthieu Van Tilbeurgh, Cécile Hérate, Anne-Sophie Gallouët, Francis Relouzat, Sylvie van der Werf, Mariangela Cavarelli, Nathalie Dereuddre-Bosquet, Marit J. van Gils, Rogier W. Sanders, Pascal Poignard, Roger Le Grand, Winfried Weissenhorn
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2025-03-01
Serie:npj Vaccines
Accesso online:https://doi.org/10.1038/s41541-025-01113-0
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