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Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma

Abstract Background The pattern recognition receptor Dectin-1 was initially discovered to play a pivotal role in mediating pulmonary antifungal immunity and promoting neutrophil-driven inflammation. Recent studies have revealed that Dectin-1 is overexpressed in asthma, but the specific mechanism rem...

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Main Authors: Runjin Cai, Xiaoxiao Gong, Xiaozhao Li, Yuanyuan Jiang, Shuanglinzi Deng, Jiale Tang, Huan Ge, Chendong Wu, Huan Tang, Guo Wang, Lei Xie, Xuemei Chen, Xinyue Hu, Juntao Feng
Format: Artigo
Language:Inglês
Published: BMC 2024-03-01
Series:Respiratory Research
Subjects:
Asthma
Dectin-1
Caspase-11
Pyroptosis
Neutrophil
Online Access:https://doi.org/10.1186/s12931-024-02743-z
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