Improving the Solubility of Formononetin and Enabling Hydrogel-Based Wound-Oriented Applications Through the Effect of Hot-Melt Extrusion

Isoflavones are plant-derived polyphenols with broad biological activity; however, their application in topical formulations is limited by poor aqueous solubility. The aim of this study was to enhance the aqueous solubility of formononetin using a solvent-free hot-melt extrusion (HME) approach and t...

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Bibliografiska uppgifter

Huvudupphov:	Anna Gościniak, Natalia Rosiak, Miłosz Ignacyk, Barbara Kaproń-Plech, Piotr Trzaskoma, Bozena Michniak-Kohn, Judyta Cielecka-Piontek
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	MDPI AG 2026-02-01
Serie:	Applied Sciences
Ämnen:	formononetin isoflavones hot-melt extrusion cyclodextrins amorphous solid dispersions solubility enhancement
Länkar:	https://www.mdpi.com/2076-3417/16/4/1975
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