Improving production of Streptomyces griseus trypsin for enzymatic processing of insulin precursor

Abstract Background Trypsin has many applications in food and pharmaceutical manufacturing. Although commercial trypsin is usually extracted from porcine pancreas, this source carries the risks of infectivity and immunogenicity. Microbial Streptomyces griseus trypsin (SGT) is a prime alternative bec...

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Autores principales:	Yunfeng Zhang, Qixing Liang, Chuanzhi Zhang, Juan Zhang, Guocheng Du, Zhen Kang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2020-04-01
Colección:	Microbial Cell Factories
Materias:	Streptomyces griseus trypsin Autolysis Unfolded protein response (UPR) Pichia pastoris Insulin
Acceso en línea:	http://link.springer.com/article/10.1186/s12934-020-01338-9
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