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Two-Pore-Domain Potassium Channel TREK–1 Mediates Pulmonary Fibrosis through Macrophage M2 Polarization and by Direct Promotion of Fibroblast Differentiation

Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by myofibroblast proliferation and abnormal accumulation of extracellular matrix in the lungs. After lung injury, M2 macrophages mediate the pathogenesis of pulmonary fibrosis by secreting fibrotic cytokines that promote myof...

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Main Authors: Yunna Zhang, Jiafeng Fu, Yang Han, Dandan Feng, Shaojie Yue, Yan Zhou, Ziqiang Luo
Format: Artigo
Language:Inglês
Published: MDPI AG 2023-04-01
Series:Biomedicines
Subjects:
lung fibrosis
TREK–1
M2 macrophage
fibroblast
myofibroblast
p38
Online Access:https://www.mdpi.com/2227-9059/11/5/1279
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