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Inhibition of PADI2-mediated vimentin citrullination alleviates silica-induced pulmonary fibrosis in mice

Abstract Silicosis remains a critical occupational health concern worldwide, lacking effective treatments due to unclear mechanisms. In this study, we investigated the citrullinated proteomic profile and its effects in mice exposed to silica. Our findings demonstrated elevated levels of citrullinate...

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Principais autores: Fuyu Jin, Yaqian Li, Tian Li, Shupeng Liu, Dingjie Xu, Heliang Liu, Zhongqiu Wei, Xuemin Gao, Na Mao, Wenchen Cai, Yiwei Shi, Haibo Zhang, Hong Xu
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-03-01
Serier:Particle and Fibre Toxicology
Fag:
Silicosis
Peptidylarginine deiminases
Citrullinated vimentin
Early growth response protein 1
Online adgang:https://doi.org/10.1186/s12989-026-00671-y
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