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Structure of the human volume regulated anion channel

SWELL1 (LRRC8A) is the only essential subunit of the Volume Regulated Anion Channel (VRAC), which regulates cellular volume homeostasis and is activated by hypotonic solutions. SWELL1, together with four other LRRC8 family members, potentially forms a vastly heterogeneous cohort of VRAC channels wit...

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Main Authors: Jennifer M Kefauver, Kei Saotome, Adrienne E Dubin, Jesper Pallesen, Christopher A Cottrell, Stuart M Cahalan, Zhaozhu Qiu, Gunhee Hong, Christopher S Crowley, Tess Whitwam, Wen-Hsin Lee, Andrew B Ward, Ardem Patapoutian
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
ion channel structure
cryo-electron microscopy
volume regulated anion channel
Online Access:https://elifesciences.org/articles/38461
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