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Proteome Differences in Smooth Muscle Cells from Diabetic and Non-Diabetic Abdominal Aortic Aneurysm Patients Reveal Metformin-Induced Mechanisms

<b>Aims</b>: Surgery remains the only definitive treatment option for abdominal aortic aneurysms (AAA), as no conclusive evidence supports drug effectiveness in preventing AAA growth. Although type 2 diabetes (T2D) is an important cardiovascular risk factor, patients with T2D show reduced AAA presen...

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Main Authors: Tara A. R. van Merrienboer, Karlijn B. Rombouts, Albert C. W. A. van Wijk, Jaco C. Knol, Thang V. Pham, Sander R. Piersma, Connie R. Jimenez, Ron Balm, Kak K. Yeung, Vivian de Waard
Format: Artigo
Language:Inglês
Published: MDPI AG 2025-09-01
Series:Medical Sciences
Subjects:
abdominal
aortic aneurysm
proteomics
redox
antioxidants
smooth muscle cell
Online Access:https://www.mdpi.com/2076-3271/13/3/184
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