CHAC1 in urological tumors: contextual dualism and therapeutic implications

CHAC1, a glutathione-degrading enzyme, governs context-dependent pathophysiological processes in urological malignancies through modulation of endoplasmic reticulum stress and ferroptotic pathways. In clear cell renal cell carcinoma (ccRCC), CHAC1 exhibits stage-specific functional duality: downregu...

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Autori principali:	Deyu Wang, Yongquan Wan, Yunxiang Li, Yuan Ren, Jiakai Ma, Si Ge, Ziqiang Zeng, Zuoping Wang, Lei Zhen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-08-01
Serie:	Frontiers in Oncology
Soggetti:	CHAC1 glutathione metabolism ferroptosis endoplasmic reticulum stress prognostic biomarker drug resistance
Accesso online:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1610915/full
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