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The PP2A phosphatase counteracts the function of the 9-1-1 axis in checkpoint activation

Summary: DNA damage elicits a checkpoint response depending on the Mec1/ATR kinase, which detects the presence of single-stranded DNA and activates the effector kinase Rad53/CHK2. In Saccharomyces cerevisiae, one of the signaling circuits leading to Rad53 activation involves the evolutionarily conse...

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Ngā kaituhi matua: Erika Casari, Paolo Pizzul, Carlo Rinaldi, Marco Gnugnoli, Michela Clerici, Maria Pia Longhese
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2023-11-01
Rangatū:Cell Reports
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Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2211124723013724
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