Obinutuzumab induces lysosomal destabilization via sphingomyelin-dependent inhibition of TRPML2

Abstract Obinutuzumab (OBI), a type II glycoengineered anti-CD20 antibody, induces direct cell death (DCD) in B-cell lymphomas more effectively than rituximab, yet the upstream mechanisms underlying this activity remain unclear. Here, we identify a lipid–ion channel axis linking antibody internaliza...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Jinkyung Oh, Narae Jin, Sunhyung Kwon, Changsin Lee, Hyungjun Baek, Donghyuk Lee, Joo Young Kim
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Nature Portfolio 2026-02-01
Sarja:	Scientific Reports
Aiheet:	Obinutuzumab TRPML2 Lysosomal membrane permeabilization Sphingomyelin Endocytosis B-cell lymphoma
Linkit:	https://doi.org/10.1038/s41598-026-38087-5
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