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TMEM182 inhibits myocardial differentiation of human iPS cells by maintaining the activated state of Wnt/β‐catenin signaling through an increase in ILK expression

Abstract Transmembrane protein 182 (TMEM182) is notably abundant in muscle and adipose tissue, but its role in the heart remains unknown. This study examined the contribution of TMEM182 in the differentiation of human induced pluripotent stem cells (hiPSCs) into cardiomyocytes. For this, we generate...

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Principais autores: Hirofumi Morihara, Shunichi Yokoe, Shigeo Wakabayashi, Shinji Takai
Formato: Artigo
Idioma:Inglês
Publicado: Wiley 2024-11-01
Series:FASEB BioAdvances
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Acceso en liña:https://doi.org/10.1096/fba.2024-00086
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