HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux

HIV infection, through the actions of viral accessory protein Nef, impairs activity of cholesterol transporter ABCA1, inhibiting cholesterol efflux from macrophages and elevating the risk of atherosclerosis. Nef also induces lipid raft formation. In this study, we demonstrate that these activities a...

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Detalhes bibliográficos

Principais autores:	Huanhuan L. Cui, Angela Grant, Nigora Mukhamedova, Tatiana Pushkarsky, Lucas Jennelle, Larisa Dubrovsky, Katharina Gaus, Michael L. Fitzgerald, Dmitri Sviridov, Michael Bukrinsky
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2012-04-01
coleção:	Journal of Lipid Research
Assuntos:	cholesterol metabolism cholesterol trafficking ATP binding cassette transporter A1 human immunodeficiency virus
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0022227520405632
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