IgM cleavage by Streptococcus suis reduces IgM bound to the bacterial surface and is a novel complement evasion mechanism

Streptococcus suis (S. suis) causes meningitis, arthritis and endocarditis in piglets. The aim of this study was to characterize the IgM degrading enzyme of S. suis (IdeSsuis) and to investigate the role of IgM cleavage in evasion of the classical complement pathway and pathogenesis. Targeted mutage...

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Autors principals:	Viktoria Rungelrath, Christine Weiße, Nicole Schütze, Uwe Müller, Marita Meurer, Manfred Rohde, Jana Seele, Peter Valentin-Weigand, Michael Kirschfink, Andreas Beineke, Wieland Schrödl, René Bergmann, Christoph Georg Baums
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis Group 2018-12-01
Col·lecció:	Virulence
Matèries:	Streptococcus suis IdeSsuis IgM opsonization cysteine protease IdeS-family protease
Accés en línia:	http://dx.doi.org/10.1080/21505594.2018.1496778
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