Forward genetic screen using a gene-breaking trap approach identifies a novel role of grin2bb-associated RNA transcript (grin2bbART) in zebrafish heart function

LncRNA-based control affects cardiac pathophysiologies like myocardial infarction, coronary artery disease, hypertrophy, and myotonic muscular dystrophy. This study used a gene-break transposon (GBT) to screen zebrafish (Danio rerio) for insertional mutagenesis. We identified three insertional mutan...

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Auteurs principaux:	Ramcharan Singh Angom, Adita Joshi, Ashok Patowary, Ambily Sivadas, Soundhar Ramasamy, Shamsudheen K. V., Kriti Kaushik, Ankit Sabharwal, Mukesh Kumar Lalwani, Subburaj K., Naresh Singh, Vinod Scaria, Sridhar Sivasubbu
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2024-03-01
Collection:	Frontiers in Cell and Developmental Biology
Sujets:	insertional mutagenesis gene breaking trap calcium homeostasis grin2bb grin2bbART hypertrophy
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1339292/full
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