Imbalance between genomic gain and loss identifies high-risk neuroblastoma patients with worse outcomes

Survival in high-risk neuroblastoma (HR-NB) patients remains poor despite multimodal treatment. We aimed to identify HR-NB patients with worse outcomes by analyzing the genomic instability derived from segmental chromosomal aberrations. We calculated 3 genomic instability indexes for primary tumor S...

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Autori principali:	Beatriz Fernández-Blanco, Ana Pilar Berbegall, Susana Martin-Vañó, Victoria Castel, Samuel Navarro, Rosa Noguera
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2021-01-01
Serie:	Neoplasia: An International Journal for Oncology Research
Soggetti:	Copy number load Copy number aberration burden Net genomic load Genomic imbalance Segmental chromosomal aberrations
Accesso online:	http://www.sciencedirect.com/science/article/pii/S147655862030169X
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