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A Digital Twin of the Angiotensin II Receptor Blocker Losartan: Physiologically Based Modeling of Blood Pressure Regulation

<b>Background/Objectives:</b> Losartan, an angiotensin II receptor blocker (ARB) used to treat hypertension and heart failure, shows significant variability in pharmacokinetics (PK) and pharmacodynamics (PD) among individuals. <b>Methods:</b> In this study, we developed a physiologically based pharm...

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Principais autores: Ennie Tensil, Mariia Myshkina, Matthias König
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-02-01
Serier:Pharmaceutics
Fag:
losartan
angiotensin II receptor blocker
ARB
PBPK/PD modeling
pharmacokinetics
pharmacodynamics
Online adgang:https://www.mdpi.com/1999-4923/18/2/262
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