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Primaquine in glucose-6-phosphate dehydrogenase deficiency: an adaptive pharmacometric assessment of ascending dose regimens in healthy volunteers

Background: Primaquine is an 8-aminoquinoline antimalarial. It is the only widely available treatment to prevent relapses of Plasmodium vivax malaria. The 8-aminoquinolines cause dose-dependent haemolysis in glucose-6-phosphate dehydrogenase deficiency (G6PDd). G6PDd is common in malaria endemic are...

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Principais autores: Sasithon Pukrittayakamee, Podjanee Jittamala, James A Watson, Borimas Hanboonkunupakarn, Pawanrat Leungsinsiri, Kittiyod Poovorawan, Kesinee Chotivanich, Germana Bancone, Cindy S Chu, Mallika Imwong, Nicholas PJ Day, Walter RJ Taylor, Nicholas J White
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2024-02-01
Serier:eLife
Fag:
primaquine
glucose-6-phosphate dehydrogenase deficiency
radical cure
Online adgang:https://elifesciences.org/articles/87318
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