Induction and decay of functional complement-fixing antibodies by the RTS,S malaria vaccine in children, and a negative impact of malaria exposure

Abstract Background Leading malaria vaccine, RTS,S, is based on the circumsporozoite protein (CSP) of sporozoites. RTS,S confers partial protection against malaria in children, but efficacy wanes relatively quickly after primary immunization. Vaccine efficacy has some association with anti-CSP IgG;...

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Detalhes bibliográficos

Principais autores:	Liriye Kurtovic, Paul A. Agius, Gaoqian Feng, Damien R. Drew, Itziar Ubillos, Jahit Sacarlal, John J. Aponte, Freya J. I. Fowkes, Carlota Dobaño, James G. Beeson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-02-01
coleção:	BMC Medicine
Assuntos:	Antibody function Circumsporozoite protein Complement Malaria Plasmodium falciparum RTS,S
Acesso em linha:	http://link.springer.com/article/10.1186/s12916-019-1277-x
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