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Two origins for the gene encoding alpha-isopropylmalate synthase in fungi.

BACKGROUND: The biosynthesis of leucine is a biochemical pathway common to prokaryotes, plants and fungi, but absent from humans and animals. The pathway is a proposed target for antimicrobial therapy. METHODOLOGY/PRINCIPAL FINDINGS: Here we identified the leuA gene encoding alpha-isopropylmalate sy...

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Detalles Bibliográficos
Principais autores: Erica M Larson, Alexander Idnurm
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Acceso en liña:http://europepmc.org/articles/PMC2904702?pdf=render
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