Predicting the protein interaction landscape of a free-living bacterium with pooled-AlphaFold3

Abstract Accurate prediction of protein complex structures by AlphaFold3 and similar programs has been used to predict the presence of protein–protein interactions (PPIs), but this technique has never been applied to an entire genome due to onerous computational requirements and questionable utility...

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Principais autores:	Horia Todor, Lili M Kim, Jürgen Jänes, Hannah N Burkhart, Seth A Darst, Pedro Beltrao, Carol A Gross
Format:	Artigo
Jezik:	Inglês
Izdano:	Springer Nature 2026-01-01
Serija:	Molecular Systems Biology
Teme:	AlphaFold3 Mycoplasma Protein-Protein Interactions Structural Biology
Online dostop:	https://doi.org/10.1038/s44320-026-00189-7
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