Structural and Compound ALK Resistance Mutations: A Unified Framework to Understand Lorlatinib Failure and Beyond
Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) have dramatically transformed the clinical management of ALK-rearranged non-small cell lung cancer (NSCLC). Successive generations of ALK inhibitors have been developed to overcome resistance mediated by kinase domain mutations, culm...
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| Main Author: | |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
MDPI AG
2026-06-01
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| Series: | Journal of Respiration |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-527X/6/2/11 |
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