Xanthine oxidase mediates hypoxia-inducible factor-2α degradation by intermittent hypoxia.

Sleep-disordered breathing with recurrent apnea produces chronic intermittent hypoxia (IH). We previously reported that IH leads to down-regulation of HIF-2α protein via a calpain-dependent signaling pathway resulting in oxidative stress. In the present study, we delineated the signaling pathways as...

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Principais autores:	Jayasri Nanduri, Damodara Reddy Vaddi, Shakil A Khan, Ning Wang, Vladislav Makerenko, Nanduri R Prabhakar
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Public Library of Science (PLoS) 2013-01-01
סדרה:	PLoS ONE
גישה מקוונת:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075838&type=printable
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