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Δlpp mutant E. coli reduces lipid content in Caenorhabditis elegans via phosphatidylglycerol-mediated inhibition of fatty acid biosynthesis

ABSTRACT Although the gut microbiota is known to influence host metabolism, how specific bacterial genetic mutations modulate lipid metabolism remains unclear. In this study, we integrated in vivo lipid visualization, whole-transcriptome RNA sequencing, and lipidomics to investigate the effects of t...

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Main Authors: Dianshuang Zhou, Liwei Tang, Mengdie Ni, Wen Yang, Xiangming Wang, Ying Li, Zuobin Zhu
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2026-07-01
Series:mSystems
Subjects:
mutant E. coli
lipid
phosphatidylglycerol
Caenorhabditis elegans
Online Access:https://journals.asm.org/doi/10.1128/msystems.00155-26
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