Spatially-restricted inflammation-induced senescent-like glia in multiple sclerosis and patient-derived organoids

Abstract In multiple sclerosis (MS), chronic compartmentalized inflammation is thought to drive relentless clinical deterioration. Here, we investigate the link between unresolved parenchymal inflammation and cellular senescence in MS progression. Single-cell transcriptomic analysis of human brain t...

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Autors principals:	Francesca Fagiani, Edoardo Pedrini, Maria Sofia Martire, Gaia Gastoldi, Colin Vanden Bulcke, Jing-Ping Lin, Dragan Maric, Elena Brambilla, Francesca Ruffini, Carolina Peri, Peter A. Calabresi, Pietro Maggi, Paola Panina-Bordignon, Gianvito Martino, Daniel S. Reich, Martina Absinta
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-09-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-025-63371-9
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