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Genomic attributes of homology-directed DNA repair deficiency in metastatic prostate cancer

Cancers with homology-directed DNA repair (HRR) deficiency exhibit high response rates to poly(ADP-ribose) polymerase inhibitors (PARPi) and platinum chemotherapy. Though mutations disrupting BRCA1 and BRCA2 associate with HRR deficiency (HRRd), patterns of genomic aberrations and mutation signature...

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Principais autores: Navonil De Sarkar, Sayan Dasgupta, Payel Chatterjee, Ilsa Coleman, Gavin Ha, Lisa S. Ang, Emily A. Kohlbrenner, Sander B. Frank, Talina A. Nunez, Stephen J. Salipante, Eva Corey, Colm Morrissey, Eliezer Van Allen, Michael T. Schweizer, Michael C. Haffner, Radhika Patel, Brian Hanratty, Jared M. Lucas, Ruth F. Dumpit, Colin C. Pritchard, Robert B. Montgomery, Peter S. Nelson
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical investigation 2021-12-01
coleção:JCI Insight
Assuntos:
Oncology
Acesso em linha:https://doi.org/10.1172/jci.insight.152789
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