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Distinct metabolome and flux responses in the retinal pigment epithelium to cytokines associated with age-related macular degeneration: comparison of ARPE-19 cells and eyecups

Abstract Age-related macular degeneration (AMD) is associated with chronic inflammation of the retinal pigment epithelium (RPE) and elevated cytokines including TNFα, TGF-β, IL-6, and IL-1β. As a metabolic intermediary supporting aerobic glycolysis in the adjacent photoreceptors, the RPE’s metabolic...

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Gardado en:
Principais autores: David S. Hansman, Kelly Lim, Daniel Thomas, Robert J. Casson, Daniel J. Peet
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2025-04-01
Series:Scientific Reports
Assuntos:
Age-related macular degeneration
Retinal pigment epithelium
Metabolism
Retina inflammation
Cytokines
Metabolic ecosystem
Acceso en liña:https://doi.org/10.1038/s41598-025-93882-w
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