Oxidative Insults and Mitochondrial DNA Mutation Promote Enhanced Autophagy and Mitophagy Compromising Cell Viability in Pluripotent Cell Model of Mitochondrial Disease

Dysfunction of mitochondria causes defects in oxidative phosphorylation system (OXPHOS) and increased production of reactive oxygen species (ROS) triggering the activation of the cell death pathway that underlies the pathogenesis of aging and various diseases. The process of autophagy to degrade dam...

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Egile Nagusiak:	Dar-Shong Lin, Yu-Wen Huang, Che-Sheng Ho, Pi-Lien Hung, Mei-Hsin Hsu, Tuan-Jen Wang, Tsu-Yen Wu, Tsung-Han Lee, Zo-Darr Huang, Po-Chun Chang, Ming-Fu Chiang
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2019-01-01
Saila:	Cells
Gaiak:	mitochondrial diseases MELAS iPS cells autophagy mitophagy
Sarrera elektronikoa:	http://www.mdpi.com/2073-4409/8/1/65
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