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In-Silico Characterization of von Willebrand Factor Bound to FVIII

Factor VIII belongs to the coagulation cascade and is expressed as a long pre-protein (mature form, 2351 amino acids long). FVIII is deficient or defective in hemophilic A patients, who need to be treated with hemoderivatives or recombinant FVIII substitutes, i.e., biologic drugs. The interaction be...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Valentina Drago, Luisa Di Paola, Claire Lesieur, Renato Bernardini, Claudio Bucolo, Chiara Bianca Maria Platania
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-08-01
Schriftenreihe:Applied Sciences
Schlagworte:
hemophilia A
FVIII
von Willebrand Factor
protein contact networks
bioinformatics
biologic drugs
Online-Zugang:https://www.mdpi.com/2076-3417/12/15/7855
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