Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way

Abstract Background Calcific aortic valve disease (CAVD) is the most prevalent valvular disease worldwide. However, no effective treatment could delay or prevent the progression of the disease due to the poor understanding of its pathological mechanism. Many studies showed that metformin exerted ben...

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Autori principali:	Qiao En, Huang Zeping, Wang Yuetang, Wang Xu, Wang Wei
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2021-12-01
Serie:	Molecular Medicine
Soggetti:	Metformin Calcific aortic valve disease Calcification Aortic valve interstitial cells PI3K/AKT signaling pathway Apoptosis
Accesso online:	https://doi.org/10.1186/s10020-021-00416-x
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