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Treatment-Resistant Major Depression:Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy

Major depressive disorder (MDD) remains a huge personal and societal encumbrance. Particularly burdensome is a virulent subtype of MDD, treatment resistant major depression (TMRD), which afflicts 15-30% of MDD patients. There has been recent interest in N-methyl-D-aspartate (receptors (NMDARs) as t...

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Principais autores: Charles eZorumski, Peter eNagele, Stephen James Mennerick, Charles eConway
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015-12-01
coleção:Frontiers in Psychiatry
Assuntos:
Hippocampus
Ketamine
Suicide
antidepressant
metaplasticity
NMDA receptors
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fpsyt.2015.00172/full
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