Structural Analysis of the cl-Par-4 Tumor Suppressor as a Function of Ionic Environment

Prostate apoptosis response-4 (Par-4) is a proapoptotic tumor suppressor protein that has been linked to a large number of cancers. This 38 kilodalton (kDa) protein has been shown to be predominantly intrinsically disordered in vitro. In vivo, Par-4 is cleaved by caspase-3 at Asp-131 to generate the...

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Principais autores:	Krishna K. Raut, Komala Ponniah, Steven M. Pascal
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2021-03-01
Serija:	Biomolecules
Teme:	intrinsically disordered protein (IDP) prostate apoptosis response-4 (Par-4) tumor suppressor circular dichroism (CD) spectroscopy dynamic light scattering (DLS) aggregation
Online dostop:	https://www.mdpi.com/2218-273X/11/3/386
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