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B cell treatment promotes a neuroprotective microenvironment after traumatic brain injury through reciprocal immunomodulation with infiltrating peripheral myeloid cells

Abstract Traumatic brain injury (TBI) remains a major cause of death and severe disability worldwide. We found previously that treatment with exogenous naïve B cells was associated with structural and functional neuroprotection after TBI. Here, we used a mouse model of unilateral controlled cortical...

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Principais autores: Liam J. Dwyer, Saumya Maheshwari, Emily Levy, Mark C. Poznansky, Michael J. Whalen, Ruxandra F. Sîrbulescu
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-05-01
Serier:Journal of Neuroinflammation
Fag:
Traumatic brain injury
B cells
Myeloid cells
Monocytes
Macrophages
Microglia
Online adgang:https://doi.org/10.1186/s12974-023-02812-y
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