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Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics

Abstract Background The progression of bladder cancer (BC) from non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive bladder cancer (MIBC) significantly increases disease severity. Although the tumor microenvironment (TME) plays a pivotal role in this process, the heterogeneity of tumor cel...

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Principais autores: Jianpeng Li, Yunzhong Jiang, Minghai Ma, Lu Wang, Minxuan Jing, Zezhong Yang, Mengzhao Zhang, Ke Chen, Jinhai Fan
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-01-01
Colecção:Journal of Translational Medicine
Assuntos:
TME
MIBC
NMIBC
ScRNA-seq
T cell
Epithelial cell
Acesso em linha:https://doi.org/10.1186/s12967-025-06138-6
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