Improved positive predictive value of non-invasive prenatal testing through integration with second-trimester ultrasound soft markers for fetal chromosomal abnormalities: a retrospective cohort study

BackgroundNon-invasive prenatal testing (NIPT) achieves high sensitivity for common fetal aneuploidies; however, its positive predictive value (PPV) varies substantially with population prevalence, generating a considerable false-positive burden. Current guidelines offer limited guidance on ultrasou...

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Hlavní autoři:	Dan Fu, Qian Wu, Yun Ju, Min Jiang, Suhua Zhang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-05-01
Edice:	Frontiers in Endocrinology
Témata:	cell-free fetal DNA confined placental mosaicism fetal aneuploidy non-invasive prenatal testing positive predictive value prenatal diagnosis
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fendo.2026.1831332/full
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