Beyond cell-cell contact: therapeutic potential of Eph signaling in central nervous system tumors

Eph receptor tyrosine kinases and their membrane-bound ephrin ligands constitute a unique bidirectional signaling system that orchestrates cell adhesion, migration, proliferation, and vascular patterning, processes frequently co-opted in malignancy. We conducted an integrative review of preclinical...

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Main Authors: Fernanda Cristina Poscai Ribeiro, Moisés Willian Aparecido Gonçalves, Aleff Mascarenhas Silva, Tayná Figueiredo Maciel, Reydson Alcides de Lima-Souza, João Figueira Scarini, Gary Chris Fillmore, Erika Said Abu Egal
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2025-10-01
Serija:Frontiers in Molecular Neuroscience
Teme:
Eph receptors
ephrins
glioma
glioblastoma
medulloblastoma
meningioma
Online dostop:https://www.frontiersin.org/articles/10.3389/fnmol.2025.1658651/full
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