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5-hydroxymethylcytosine but not MTAP methylation status can stratify malignant pleural mesothelioma based on the lineage of origin

Abstract Background Malignant pleural mesothelioma (MPM) is an aggressive tumor with poor prognosis, mainly associated with work or environmental exposure to asbestos. MPM’s molecular profile is largerly unexplored and effective therapies are still lacking. MPM rarely harbours those somatic genetic...

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Main Authors: Matteo Bosio, Elena Salvaterra, Francesca Datturi, Patrizia Morbini, Michele Zorzetto, Simona Inghilleri, Stefano Tomaselli, Patrizia Mangiarotti, Federica Meloni, Isa Cerveri, Giulia Maria Stella
Format: Artigo
Language:Inglês
Published: Mattioli 1885 2018-08-01
Series:Multidisciplinary Respiratory Medicine
Subjects:
Malignant pleural mesothelioma
Cancer
Epigenetics
Methylation
Lineage of origin
Online Access:http://link.springer.com/article/10.1186/s40248-018-0137-4
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