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Aggressive uveal melanoma displays a high degree of centrosome amplification, opening the door to therapeutic intervention

Abstract Uveal melanoma (UM) is the most common intraocular cancer in adults. Whilst treatment of primary UM (PUM) is often successful, around 50% of patients develop metastatic disease with poor outcomes, linked to chromosome 3 loss (monosomy 3, M3). Advances in understanding UM cell biology may in...

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Main Authors: Dorota Sabat‐Pośpiech, Kim Fabian‐Kolpanowicz, Helen Kalirai, Natalie Kipling, Sarah E Coupland, Judy M Coulson, Andrew B Fielding
Format: Artigo
Language:Inglês
Published: Wiley 2022-07-01
Series:The Journal of Pathology: Clinical Research
Subjects:
uveal melanoma
centrosome amplification
centrosome clustering
pericentriolar matrix
mitotic spindle
monosomy 3
Online Access:https://doi.org/10.1002/cjp2.272
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