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The multiple layers of RNA response in double-strand break repair

Abstract RNA molecules are now recognized as active regulators of DNA double-strand break repair. In end-joining pathways, nascent transcripts promote repair through RNA:DNA hybrids, end bridging and RNA-templated synthesis. In homologous recombination, RNA:DNA hybrids modulate DNA end resection, re...

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Bibliografische Detailangaben
Hauptverfasser: Yilin Lu, Francesca Storici, Youngkyu Jeon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2025-11-01
Schriftenreihe:Experimental and Molecular Medicine
Online-Zugang:https://doi.org/10.1038/s12276-025-01572-4
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