Basal IFNλ2/3 signaling is required for ISG expression and viral control in human intestinal epithelial cells.
Interferon-lambdas (IFNλs) serve as critical mediators of antiviral defense at mucosal surfaces. Beyond their established role in regulating innate immune responses during infection, recent evidence demonstrates that IFNλs are constitutively expressed in pathogen-free environments, termed "basal" IF...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2026-01-01
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| coleção: | PLoS Pathogens |
| Acesso em linha: | https://doi.org/10.1371/journal.ppat.1013857 |
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