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Overcoming the resistance of hepatocellular carcinoma to PD-1/PD-L1 inhibitor and the resultant immunosuppression by CD38 siRNA-loaded extracellular vesicles

Extracellular vesicles (EVs) are promising tools for drug delivery across different biological barriers. Here, we evaluated the potential of EVs-mediated delivery of CD38 siRNA on the immunosuppression of hepatocellular carcinoma (HCC). EVs were isolated from bone marrow mesenchymal stem cell cultur...

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Principais autores: Jun Deng, Hui Ke
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2023-12-01
coleção:OncoImmunology
Assuntos:
Hepatocellular carcinoma
resistance
CD38 siRNA
extracellular vesicles
macrophages
PD-1/PD-L1 inhibitor
Acesso em linha:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2152635
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