A Novel In Vitro Culture Model System to Study Merkel Cell Polyomavirus–Associated MCC Using Three-Dimensional Organotypic Raft Equivalents of Human Skin

Merkel cell polyomavirus (MCPyV) is a human polyomavirus causally linked to the development of Merkel cell carcinoma (MCC), an aggressive malignancy that largely arises within the dermis of the skin. In this study, we recapitulate the histopathology of human MCC tumors in vitro using an organotypic...

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Hauptverfasser:	Amanda S. W. Loke, B. Jack Longley, Paul F. Lambert, Megan E. Spurgeon
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-01-01
Schriftenreihe:	Viruses
Schlagworte:	Merkel cell polyomavirus Merkel cell carcinoma Merkel cells DNA tumor virus human polyomavirus organotypic rafts
Online-Zugang:	https://www.mdpi.com/1999-4915/13/1/138
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